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Updated: Oct 18, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Role of Glycosylation in Vascular Calcification
Ainun Nizar Masbuchin1,2, Mohammad Saifur Rohman2, Ping-Yen Liu1,3
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70457, Taiwan.
Abstract:
Glycosylation is an important step in post-translational protein modification. Altered glycosylation results in an abnormality that causes diseases such as malignancy and cardiovascular diseases. Recent emerging evidence highlights the importance of glycosylation in vascular calcification. Two major types of glycosylation, N-glycosylation and O-glycosylation, are involved in vascular calcification. Other glycosylation mechanisms, which polymerize the glycosaminoglycan (GAG) chain onto protein, resulting in proteoglycan (PG), also have an impact on vascular calcification. This paper discusses the role of glycosylation in vascular calcification.
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