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Updated: Oct 18, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
Gianluca Businello1, Valentina Angerilli1, Paola Parente2
1Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Abstract:
Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process.
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