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Chronic Kidney Disease: Strategies to Retard Progression

Ming-Tso Yan1,2, Chia-Ter Chao3,4,5, Shih-Hua Lin2,6

  • 1Department of Medicine, Division of Nephrology, Cathay General Hospital, School of Medicine, Fu-Jen Catholic University, Taipei 106, Taiwan.

International Journal of Molecular Sciences
|September 28, 2021
PubMed

Insights

Chronic kidney disease (CKD) management focuses on preventing progression and complications. This review details contributing factors, etiology-based treatments, complication management, and novel therapies for CKD.

Area of Science:

  • Nephrology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) involves irreversible kidney damage, leading to complications like altered mineral metabolism, anemia, metabolic acidosis, and cardiovascular events.
  • Effective therapies for CKD are challenging due to heterogeneous origins and uncertain pathogenesis.

Purpose of the Study:

  • To review factors contributing to CKD development and progression, emphasizing acute kidney injury (AKI) prevention.
  • To outline etiology-based treatment strategies for retarding CKD progression, including common and under-recognized causes.
  • To discuss approaches for ameliorating CKD complications and novel agents for counteracting disease progression.

Main Methods:

  • Literature review focusing on CKD development, progression, complications, and novel therapeutic agents.
  • Synthesis of current knowledge on risk factors, treatment strategies, and management of CKD complications.
  • Exploration of emerging therapeutic targets and agents for CKD.

Main Results:

  • Identified key factors contributing to CKD, with emphasis on preventing AKI.
  • Presented etiology-based treatment strategies for various CKD causes.
  • Summarized approaches to manage common CKD complications and highlighted novel therapeutic agents.

Conclusions:

  • Comprehensive management of CKD requires addressing its multifactorial nature, including prevention, etiology-specific treatments, complication management, and exploration of novel therapies.
  • Avoiding AKI is crucial in preventing CKD development and progression.
  • Novel agents show promise in counteracting CKD progression, offering new therapeutic avenues.
Keywords:
acute kidney injurychronic kidney diseaserenal progressiontherapy for renal failure

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