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Updated: Oct 18, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Selected Essential and Toxic Chemical Elements in Hypothyroidism-A Literature Review (2001-2021)
Anna Błażewicz1, Patrycja Wiśniewska1, Katarzyna Skórzyńska-Dziduszko2
1Department of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Faculty of Biomedicine, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland.
Abstract:
Thyroid hormones are known for controlling metabolism of lipids, carbohydrates, proteins, minerals, and electrolytes and for regulating body temperature. Normal thyroid status depends on the chemical/elemental composition of body fluids and tissues, which changes depending on physiological state, lifestyle and environment. A deficiency or excess of certain essential chemical elements (selenium, zinc, copper, iron or fluorine) or exposure to toxic (cadmium or lead) or potentially toxic elements (manganese or chromium) interacts with thyroid hormone synthesis and may disturb thyroid homeostasis. In our review, accessible databases (Scopus, PubMed and Web of Science) were searched for articles from 2001-2021 on the influence of selected chemical elements on the development of hypothyroidism. Our review adopted some of the strengths of a systematic review. After non-eligible reports were rejected, 29 remaining articles were reviewed. The review found that disruption of the physiological levels of elements in the body adversely affects the functioning of cells and tissues, which can lead to the development of disease.
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