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Xanthone Glucosides: Isolation, Bioactivity and Synthesis.

Qing Huang1,2, Youyi Wang1,2, Huaimo Wu1,2

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Molecules (Basel, Switzerland)
|September 28, 2021
PubMed
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Xanthone glucosides, plant compounds with medicinal properties, are reviewed for their isolation, structure, bioactivity, and synthesis. This review covers their potential therapeutic applications.

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacognosy

Background:

  • Xanthones are plant secondary metabolites with diverse bioactivities, including antioxidant, antibacterial, antimalarial, antituberculosis, and cytotoxic properties.
  • Xanthone glucosides represent a significant subclass, potentially exhibiting enhanced solubility and pharmacological activity post-glycosylation.
  • A critical review specifically on xanthone glucosides is currently lacking in the scientific literature.

Purpose of the Study:

  • To provide a comprehensive review of naturally occurring xanthone glucosides.
  • To consolidate information on the isolation, structure elucidation, bioactivity, and synthesis of xanthone glucosides.
  • To highlight the therapeutic potential and research gaps concerning these compounds.

Main Methods:

Keywords:
9H-xanthen-9-onechemical synthesispharmacological activityxanthone C-glucosidexanthone O-glucoside

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  • Extensive literature survey focusing on naturally occurring xanthone glucosides.
  • Analysis of reported data on isolation techniques and structural characterization.
  • Compilation and assessment of studies detailing the bioactivities and synthetic routes.

Main Results:

  • Identification and cataloging of various naturally occurring xanthone glucosides from diverse botanical sources.
  • Detailed summary of established isolation, structure determination, and synthesis methodologies.
  • Overview of the broad spectrum of bioactivities reported for xanthone glucosides.

Conclusions:

  • Xanthone glucosides are a promising class of natural products with significant therapeutic potential.
  • This review serves as a foundational resource for future research into xanthone glucoside chemistry and pharmacology.
  • Further investigation into their synthesis and bioactivity is warranted to explore their full medicinal applications.