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LRP1B: A Giant Lost in Cancer Translation

Catarina Príncipe1,2, Isabel J Dionísio de Sousa3,4, Hugo Prazeres1,5

  • 1i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

Pharmaceuticals (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Low-density lipoprotein receptor-related protein 1B (LRP1B) is a key gene frequently altered in human cancer. Advances reveal its crucial role, positioning LRP1B as a potential therapeutic target and prognostic biomarker.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Low-density lipoprotein receptor-related protein 1B (LRP1B) is a large cell surface receptor in the LDLR family.
  • LRP1B is frequently inactivated in human cancers and often considered a tumor suppressor.
  • Its large size has historically limited comprehensive study.

Purpose of the Study:

  • To review current knowledge on LRP1B structure, ligands, and function in cancer.
  • To highlight how technological advancements improve LRP1B research.
  • To underscore LRP1B's emerging significance in oncology.

Main Methods:

  • Literature review of LRP1B studies.
  • Analysis of genetic and epigenetic inactivation mechanisms.
  • Exploration of recent technical and methodological advancements.

Main Results:

  • LRP1B plays diverse roles in cellular processes, including cargo transport and signaling.
  • Genetic and epigenetic alterations frequently impact LRP1B in various cancers.
  • New methods facilitate better understanding of LRP1B expression and mutation status.

Conclusions:

  • LRP1B is increasingly recognized for its relevance in cancer biology.
  • LRP1B holds potential as a therapeutic target.
  • LRP1B may serve as a prognostic and predictive biomarker for cancer therapy response.
Keywords:
LRP1Bbiomarkercancerendocytic receptorimmune checkpoint inhibitorspredictor of responseprognosistumor suppressor

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