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Inulin and Its Application in Drug Delivery
Franklin Afinjuomo1, Sadikalmahdi Abdella1, Souha H Youssef1
1Pharmaceutical Innovation and Development Group, Clinical and Health Sciences, University of South Australia, Adelaide 5001, Australia.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2021
Summary
Inulin, a biodegradable polysaccharide, offers unique advantages as a drug delivery carrier due to its structure and targeting capabilities. Chemical modification of inulin enhances drug bioavailability, cellular uptake, and controlled release for advanced therapeutics.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Inulin is a biodegradable polysaccharide with inherent properties suitable for drug delivery.
- Its flexible structure, protective effects, and organ targeting ability make it superior to other polysaccharides.
- The presence of hydroxyl groups allows for chemical modification to improve drug delivery characteristics.
Purpose of the Study:
- To review various inulin-based drug delivery systems.
- To discuss the preparation and applications of these systems.
- To highlight inulin's potential as a multifunctional scaffold for drug delivery.
Main Methods:
- Literature review of inulin drug delivery systems.
- Analysis of inulin's structural and chemical properties for drug delivery applications.
- Discussion of different inulin-based formulations including hydrogels, nanoparticles, and micelles.
Main Results:
- Inulin exhibits excellent potential as a drug delivery carrier, surpassing other biodegradable polysaccharides.
- Chemical modification of inulin significantly enhances drug bioavailability, cellular uptake, and enables targeted, sustained, and controlled release.
- Various inulin-based systems like hydrogels, nanoparticles, micelles, and prodrugs have been developed and show promising applications.
Conclusions:
- Inulin's unique characteristics make it a versatile and effective platform for advanced drug delivery.
- Modification of inulin unlocks its potential as a multifunctional scaffold for diverse therapeutic applications.
- Inulin-based drug delivery systems offer significant advantages for improving therapeutic outcomes.
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