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Published on: July 11, 2013
Manufacturing Bacteriophages (Part 1 of 2): Cell Line Development, Upstream, and Downstream Considerations
Tayfun Tanir1, Marvin Orellana1, Aster Escalante1
1Amgen Bioprocessing Center, Department of Biological Engineering and Management, Keck Graduate Institute, Henry E. Riggs School of Applied Life Sciences, Claremont, CA 91711, USA.
Abstract:
Within this first part of the two-part series on phage manufacturing, we will give an overview of the process leading to bacteriophages as a drug substance, before covering the formulation into a drug product in the second part. The principal goal is to provide the reader with a comprehensive framework of the challenges and opportunities that present themselves when developing manufacturing processes for bacteriophage-based products. We will examine cell line development for manufacture, upstream and downstream processes, while also covering the additional opportunities that engineered bacteriophages present.
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