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Related Experiment Video

Updated: Oct 18, 2025

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical

Andrea Ágnes Molnár1, Márton Kolossváry1, Bálint Lakatos1

  • 1Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.

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Summary

Genetic and environmental factors influencing left ventricle (LV) systolic and diastolic function are largely independent. Systolic function is strongly genetically determined, while diastolic function is more influenced by environmental factors.

Keywords:
co-heritabilityenvironmentalgeneticleft ventriclespeckle trackingtwin

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Area of Science:

  • Cardiology
  • Genetics
  • Echocardiography

Background:

  • Limited data exist on the heritability of left ventricle (LV) systolic and diastolic parameters and their interdependence.
  • Understanding the genetic and environmental contributions to LV function is crucial for deciphering heart failure pathomechanisms.

Purpose of the Study:

  • To assess the magnitude of common and independent genetic and environmental factors defining LV systolic and diastolic function.
  • To investigate the shared and specific influences on these cardiac parameters.

Main Methods:

  • Analysis of 184 asymptomatic twins using transthoracic echocardiography.
  • Measurement of LV systolic (strain, rotation) and diastolic (inflow, annulus velocity, deceleration time) parameters.
  • Application of genetic structural equation models to quantify genetic (Ac, As) and environmental (Ec, Es) contributions.

Main Results:

  • LV systolic parameters exhibited no common genetic or environmental heritability, with strong specific genetic (As: 57-77%) and environmental (Es: 24-43%) influences.
  • Diastolic LV parameters were primarily determined by common genetic (Ac: 9-40%) and environmental (Ec: 11-49%) effects.
  • No common genetic or environmental factors were shared between systolic and diastolic LV parameters.

Conclusions:

  • LV systolic parameters are predominantly influenced by specific genetic factors and show no overlap with diastolic parameters.
  • Diastolic LV function is mainly affected by common environmental influences, suggesting shared pathways for deterioration.
  • Differentiating the genetic and environmental impacts on systolic and diastolic LV function aids in understanding heart failure subtypes.