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Relation between Exogenous Insulin and Cognitive Function in Type 2 Diabetes Mellitus.
Diana Šimonienė1,2, Džilda Veličkienė1,2
1Department of Endocrinology, Academy of Medicine, Lithuanian University of Health Sciences (LUHS), 44307 Kaunas, Lithuania.
Medicina (Kaunas, Lithuania)
|September 28, 2021
Summary
Higher insulin doses may improve cognitive function in type 2 diabetes patients. This study found that increased exogenous insulin supply positively impacts cognition, particularly in those with poorly controlled diabetes.
Area of Science:
- Neuroscience
- Endocrinology
- Metabolic Disorders
Background:
- The brain's complex response to insulin is not fully understood.
- Exogenous insulin's role in cognitive function requires further investigation.
Purpose of the Study:
- To investigate the impact of exogenous insulin dosage on mild cognitive impairment (MCI) in type 2 diabetes patients.
- To explore if insulin doses and other risk factors mediate the relationship between insulin and cognitive function.
Main Methods:
- 100 type 2 diabetes patients (age ≥ 40) were divided into high (>1 IU/kg/day) and low (<1 IU/kg/day) insulin requirement groups.
- Cognitive function was assessed using the MoCA questionnaire.
- Plasma lipid and uric acid levels were analyzed.
Main Results:
- Mild cognitive impairment (MCI) prevalence was high in both normal and high insulin requirement groups (84.8% and 72.5%).
- Age and insulin dose were significantly associated with MCI (p=0.001 and p<0.0001, respectively).
- Insulin doses below 144 IU/d were associated with the highest risk of MCI.
Conclusions:
- Increased exogenous insulin supply appears to improve cognitive function.
- Higher insulin doses (>144 IU/d) showed a positive cognitive effect, especially in poorly controlled diabetes (HbA1c ≥ 9%).
- The high prevalence of MCI in type 2 diabetes warrants further research into high-dose insulin's protective potential.
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