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Finite Element Analysis for Biodegradable Dissolving Microneedle Materials on Skin Puncture and Mechanical
Qinying Yan1, Jiaqi Weng1, Shulin Shen1
1College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310032, China.
Polymers
|September 28, 2021
Summary
This study optimized microneedle (MNs) formulations for transdermal drug delivery. Best results showed CMC:HA for hard tips and CMC:PVA for patches, enhancing skin penetration capabilities.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Mechanical Engineering
Background:
- Microneedles (MNs) offer a promising route for transdermal drug delivery.
- Optimizing MN material properties is crucial for effective skin penetration and drug release.
Purpose of the Study:
- To investigate the mechanical properties of microneedles (MNs) prepared using micro-molding technology.
- To determine optimal material formulations for microneedle tips and patches for transdermal drug delivery.
Main Methods:
- Microneedles (MNs) were fabricated using micro-molding technology.
- Mechanical properties (Young's modulus, Poisson's ratio, compression breaking force) were measured using a texture analyzer.
- COMSOL Multiphysics was used for structural mechanics simulations to analyze material stress resistance.
Main Results:
- The hardest microneedle tip material comprised 15% solids content with a 1:2 (w/w) carboxymethylcellulose (CMC): hyaluronic acid (HA) ratio.
- A 10% solids content with a 1:5 (w/w) CMC: polyvinyl alcohol (PVA) ratio was identified as suitable for microneedle patch fabrication.
- Simulation analysis correlated mechanical properties with the force required for dissolving microneedles (DMNs) to penetrate skin.
Conclusions:
- Material composition significantly influences the mechanical properties and skin penetration ability of microneedles.
- Optimized formulations of CMC, polyvinyl pyrrolidone (PVP), PVA, and HA enable the development of effective microneedle-based transdermal drug delivery systems.
