Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The polymorphonuclear leukocyte.

M Baggiolini, U Bretz, B Dewald

    Agents and Actions
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Polymorphonuclear leukocytes (PMNs) release tissue-damaging enzymes during inflammation. These enzymes, stored in granules, can degrade tissue components and potentially boost immune responses in chronic inflammatory conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Introduction to chemokines and chemokine antagonists.

    Ernst Schering Research Foundation workshop·2004
    Same author

    The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC.

    European journal of immunology·2001
    Same author

    Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries.

    European journal of immunology·2001
    Same author

    Is dimerization of chemokine receptors functionally relevant?

    Science's STKE : signal transduction knowledge environment·2001
    Same author

    Chemokines in pathology and medicine.

    Journal of internal medicine·2001
    Same author

    Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.

    Blood·2001
    Same journal

    Classification and biological distribution of histamine receptor sub-types. 1975.

    Agents and actions·1994
    Same journal

    Metiamide--an orally active histamine H2-receptor antagonist. 1973.

    Agents and actions·1994
    Same journal

    A brief survey of the history of inflammation. 1978.

    Agents and actions·1994
    Same journal

    The discovery of librium. 1972.

    Agents and actions·1994
    Same journal

    Notes and documents concerning the discovery of LSD. 1970.

    Agents and actions·1994
    Same journal

    Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41,468), a selective 5-HT2-receptor antagonist. 1982.

    Agents and actions·1994
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology
    • Biochemistry

    Background:

    • Polymorphonuclear leukocytes (PMNs) are key players in inflammatory processes.
    • PMNs contain cytoplasmic granules storing various enzymes crucial for tissue function and damage.
    • Understanding PMN granule composition and enzyme function is vital for inflammatory disease research.

    Purpose of the Study:

    • To detail the enzyme content of PMN azurophil and specific granules.
    • To elucidate the role of PMN-derived enzymes in tissue degradation.
    • To explore the potential immunomodulatory effects of these enzymes in inflammation.

    Main Methods:

    • Analysis of enzyme content within PMN azurophil and specific granules.
    • Characterization of neutral proteinase activity and substrates.

    Related Experiment Videos

  • In vitro assessment of enzyme effects on B-lymphocytes.

    • Main Results:

    • Azurophil granules contain lysosomal hydrolases, neutral serine proteinases (elastase, cathepsin G), and bactericidal elements.
    • Specific granules store metalloproteinases, lysozyme, and lactoferrin, lacking lysosomal hydrolases.
    • Extracellular release of PMN enzymes during phagocytosis leads to degradation of proteoglycans and collagen.
    • In vitro studies demonstrated that PMN neutral proteinases can stimulate B-lymphocytes.

    Conclusions:

    • PMNs store a diverse array of enzymes in distinct granule types, contributing to tissue damage.
    • Released PMN enzymes degrade extracellular matrix components.
    • PMN-derived enzymes may possess immuno-potentiating activity at inflammatory sites, influencing B-lymphocyte function.