Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical energy storage of planar spiral structures based on two-dimensional nanomaterials.

Communications engineering·2026
Same author

Resolving the dynamic properties of entangled linear polymers in non-equilibrium coarse grain simulation with <i>a priori</i> scaling factors.

Nanoscale·2024
Same author

Assessing the impact of ultra-thin diamond nanothreads on the glass transition temperature of a bituminous binder.

Nanoscale advances·2023
Same author

Two-Dimensional Films Based on Graphene/Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub> and Carbon Nanotube/Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub> Nanocomposites as a Prospective Material for Lithium-Ion Batteries: Insight from Ab Initio Modeling.

Materials (Basel, Switzerland)·2023
Same author

Nanomechanics and Plasticity.

Nanomaterials (Basel, Switzerland)·2022
Same author

Effect of Fe-doping on bending elastic properties of single-crystalline rutile TiO<sub>2</sub> nanowires.

Nanoscale advances·2022

Related Experiment Video

Updated: Oct 18, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K

3D Printed Multi-Functional Scaffolds Based on Poly(ε-Caprolactone) and Hydroxyapatite Composites.

Fan Liu1, Honglei Kang2, Zhiwei Liu1

  • 1School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.

Nanomaterials (Basel, Switzerland)
|September 28, 2021
PubMed
Summary

3D printed poly(ε-caprolactone)/hydroxyapatite scaffolds promote bone regeneration in animal models. These biodegradable materials show promise for enhanced bone repair and potential tumor inhibition.

Keywords:
3D printed scaffoldsbiodegradabilitybone tissue regenerationhydroxyapatitepoly(ε-caprolactone)

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.9K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.8K

Related Experiment Videos

Last Updated: Oct 18, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.9K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.8K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Research

Background:

  • Biodegradable polymeric scaffolds are essential for bone defect repair, offering microenvironments for cell attachment and regeneration.
  • Poly(ε-caprolactone) (PCL) and hydroxyapatite (HA) composites offer promising properties for bone tissue engineering.

Purpose of the Study:

  • To develop and evaluate 3D printed PCL/HA composite scaffolds for bone defect repair.
  • To assess the biocompatibility, biodegradability, and bone regenerative potential of these scaffolds.
  • To investigate the feasibility of incorporating doxorubicin (DOX) for enhanced bone repair and potential anti-tumor effects.

Main Methods:

  • Preparation of biodegradable PCL/HA composites.
  • Fabrication of PCL/HA scaffolds using melting deposition-forming (3D printing).
  • In vitro assessments including biodegradability, cytotoxicity, and cell proliferation (MC3T3-E1 osteoblast cells).
  • In vivo studies using rat and rabbit bone defect models.

Main Results:

  • PCL/HA composites exhibited good biodegradability, low cytotoxicity, and enhanced osteoblast cell proliferation.
  • In vivo experiments demonstrated scaffold adhesion and penetration by bone cells, leading to bone tissue regeneration.
  • 3D printed PCL/HA/DOX scaffolds showed sustained drug release, enhancing bone repair and potentially inhibiting tumor cells.

Conclusions:

  • 3D printed PCL/HA composite scaffolds are effective for bone defect repair, promoting cell growth and tissue regeneration.
  • The incorporation of doxorubicin offers a multifunctional approach for enhanced bone repair and potential adjuvant cancer therapy.
  • PCL/HA composites represent a promising class of biodegradable materials for orthopedic applications.