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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Multicoagulant resistant pseudothrombocytopenia.

Nausheen Waseem¹, Bashir Hanif², Jawaid Jabbar¹

¹Laboratory, Tabba Heart Institute, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association

|September 28, 2021

Summary

This summary is machine-generated.

Pseudo thrombocytopenia, a lab error mimicking low platelets, often stems from anti-platelet antibodies. This review examines approaches to this common hematology finding, including a rare case of multi-coagulant resistant thrombocytopenia.

Keywords:

Pseudo platelet aggregation, Multicoagulant resistant thrombocytopenia, Pseudo thrombocytopenia.transplant.

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Area of Science:

Hematology
Clinical Pathology

Background:

Pseudo thrombocytopenia involves inaccurate low platelet counts from automated analyzers, despite normal platelet levels.
It is frequently caused by Ethylenediaminetetraacetic acid (EDTA)-dependent anti-platelet antibodies.
This phenomenon occurs in healthy individuals and those with cardiovascular, liver, autoimmune diseases, or malignancy.

Observation:

A case of multi-coagulant resistant dependent thrombocytopenia is presented.
The patient exhibited Anasarca and had a history of cardiomyopathy with significant cardiac chamber dilation.

Findings:

EDTA-induced pseudo thrombocytopenia is a common clinical challenge.
The case highlights a rare variant associated with multiple coagulation resistance.
Understanding the underlying mechanisms is crucial for accurate diagnosis.

Implications:

Accurate differentiation between true and pseudo thrombocytopenia is vital for appropriate patient management.
This review offers insights into diagnostic and management strategies for pseudo thrombocytopenia.
Further research into rare coagulant-resistant forms is warranted for improved clinical outcomes.