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Monocyte function in familial Mediterranean fever.

M Bar-Eli, R Gallily, M Levy

    The American Journal of the Medical Sciences
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Monocytes from familial Mediterranean fever (FMF) patients show reduced bacterial engulfment and killing capacity. These immune cell defects may contribute to FMF pathogenesis, with colchicine showing no effect.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Genetics

    Background:

    • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
    • Monocyte dysfunction is implicated in various inflammatory conditions.
    • Understanding monocyte function in FMF is crucial for elucidating disease mechanisms.

    Purpose of the Study:

    • To investigate the phagocytic and bactericidal capacities of monocytes from FMF patients.
    • To compare monocyte enzyme activities between FMF patients and healthy controls.
    • To assess the potential role of monocyte defects in FMF pathogenesis.

    Main Methods:

    • Peripheral blood monocytes were isolated from FMF patients and healthy controls.
    • Phagocytosis assays were performed using 125I-labelled Shigella flexneri and Staphylococcus albus.

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  • Bactericidal capacity against S. albus was assessed.
  • Monocyte acid phosphatase and beta-glucuronidase activities were measured.
  • The effect of colchicine on these parameters was evaluated.

    • Main Results:

    • FMF monocytes exhibited significantly lower phagocytic capacity for Shigella flexneri compared to controls.
    • Phagocytosis of Staphylococcus albus was similar between FMF patients and controls.
    • FMF monocytes displayed a 2- to 8-fold reduced bactericidal capacity against S. albus.
    • Acid phosphatase and beta-glucuronidase activities were comparable in monocytes from both groups.
    • Colchicine treatment did not alter any of the studied monocyte functions.

    Conclusions:

    • Monocytes from FMF patients have impaired phagocytic and bactericidal functions, particularly against S. albus.
    • These monocyte functional deficits may play a role in the pathogenesis of familial Mediterranean fever.
    • Colchicine, a common FMF treatment, did not improve the investigated monocyte functions.