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Bioengineering methods for organoid systems.

Jad Saleh1, Barbara Mercier1, Wang Xi1

  • 1Université de Paris, CNRS, Institut Jacques Monod, Paris, France.

Biology of the Cell
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

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Bioengineering tools enhance control over organoid development for more physiological models. These advanced methods, including genetic editing and microfluidics, improve organoid systems for research and therapeutic applications.

Area of Science:

  • Biotechnology
  • Developmental Biology
  • Bioengineering

Background:

  • Organoids are multicellular systems mimicking in vivo physiology, crucial for research and therapeutics.
  • Current organoid models face limitations in controlled development, physiological shape, and size.
  • Conventional bio-model systems using cell lines lack the complexity of organoids.

Purpose of the Study:

  • To review organoid systems, their potential, and limitations.
  • To explore bioengineering approaches for enhanced control over organoid development.
  • To highlight genetic editing and microenvironmental modification techniques.

Main Methods:

  • Review of current organoid development and bioengineering tools.
  • Focus on genetic editing for programmed organoid responses and phenotypes.
Keywords:
biotechnologiescellular microenvironmentdesigner biomaterialsorgan-on-a-chipstem cell behavior

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  • Analysis of bioengineering methods for modifying cellular environments and microfluidic systems.

    • Main Results:

    • Bioengineering offers improved control over organoid growth and development compared to autonomous systems.
    • Genetic editing enables programming of organoid responses for greater physiological relevance.
    • Advanced methods modify cellular composition, 3D micro-architectures, and microfluidic systems.

    Conclusions:

    • Bioengineering approaches significantly enhance control over organoid development.
    • Multidisciplinary, biomimetic methods are key for future organoid system advancement.
    • Improved organoid models hold promise for research and clinical applications.