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Hydrogen Production and Utilization in a Membrane Reactor

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Published on: March 10, 2023

A Versatile Compact Parahydrogen Membrane Reactor.

Patrick M TomHon¹, Suyong Han², Sören Lehmkuhl¹

¹Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry

|September 28, 2021

Summary

This summary is machine-generated.

We developed a Spin Transfer Automated Reactor (STAR) for continuous hyperpolarization using parahydrogen induced polarization (PHIP). This versatile system enables long-lasting, stable hyperpolarized signals for NMR and MRI applications.

Keywords:

NMR RASER fluidics hyperpolarization parahydrogen

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Area of Science:

Nuclear Magnetic Resonance (NMR) Spectroscopy
Magnetic Resonance Imaging (MRI)
Hyperpolarization Techniques

Background:

Parahydrogen induced polarization (PHIP) is a powerful technique for enhancing NMR/MRI signals.
Continuous hyperpolarization methods are needed for advanced metabolic studies and new physics investigations.
Existing PHIP methods often lack stability and continuous output.

Purpose of the Study:

To introduce a novel Spin Transfer Automated Reactor (STAR) for continuous hyperpolarization.
To demonstrate the versatility and efficiency of the STAR system across different magnetic field strengths.
To showcase applications of continuous hyperpolarization in metabolism and fundamental physics.

Main Methods:

Development of the Spin Transfer Automated Reactor (STAR) system.
Utilizing the Signal Amplification by Reversible Exchange (SABRE) variant of PHIP.
Integration of STAR with benchtop (1.1 T) and high-field (9.4 T) NMR magnets.
Employing semipermeable membranes for efficient parahydrogen delivery.

Main Results:

STAR produces continuous parahydrogen induced polarization (PHIP) with stability lasting hours to days.
The system enables 1H, 13C, and 15N hyperpolarization across diverse substrates, including drugs and metabolites.
STAR demonstrates versatility, operating with both benchtop and high-field NMR/MRI systems.
Continuous hyperpolarized metabolite signals were achieved for in vivo metabolic studies.
Continuous RASER signals were generated for new physics research.

Conclusions:

The STAR system provides a robust and versatile platform for continuous hyperpolarization.
This technology significantly advances the potential for in vivo metabolic imaging and exploration of novel physical phenomena.
STAR facilitates broader accessibility and application of hyperpolarization techniques in research.