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Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection

Kavitha Selvan1, Gökhan Mutlu1

  • 1Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, United States of America.

Tuberkuloz Ve Toraks
|September 28, 2021
PubMed

Insights

This case report details the first instance of Geotrichum infection in an immunocompetent individual with COVID-19. It highlights the emergence of rare fungal pathogens alongside SARS-CoV-2, necessitating clinical vigilance.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Critical Care Medicine

Background:

  • COVID-19 has been increasingly associated with secondary bacterial and fungal infections.
  • Following initial reports of Aspergillus and Candida, infections with Mucorales have risen significantly.
  • Geotrichum is a rare pathogen causing invasive disease (geotrichosis) typically in immunocompromised hosts.

Observation:

  • This report presents a unique case of Geotrichum infection in an immunocompetent host with COVID-19.
  • This represents the first documented case of Geotrichum infection in a patient with SARS-CoV-2.
  • The patient was immunocompetent, challenging the typical profile for invasive geotrichosis.

Findings:

  • The study documents a novel association between SARS-CoV-2 and invasive Geotrichum infection.
  • This case expands the spectrum of opportunistic fungal infections complicating COVID-19.
  • The pathogen identified was Geotrichum spp.

Implications:

  • Invasive fungal infections, including rare pathogens like Geotrichum, should be considered in COVID-19 patients.
  • Clinical suspicion is crucial, especially in patients with immunocompromised states or on immunosuppressive therapy.
  • This finding underscores the need for heightened awareness and diagnostic vigilance for emerging fungal coinfections in the context of viral pandemics.

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