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A 3D-cascade-microlens optofluidic chip for refractometry with adjustable sensitivity.

Jiukai Tang1,2, Guangyu Qiu1,2, Xiaole Zhang1,2

  • 1Institute of Environmental Engineering, ETH Zürich, Zürich 8093, Switzerland. jing.wang@ifu.baug.ethz.ch.

Lab on a Chip
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a 3D-cascade-microlens optofluidic chip for refractive index (RI) sensing. The chip offers adjustable sensitivity and detection range, enabling applications in environmental and biochemical analysis.

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Area of Science:

  • Optofluidics
  • Microoptics
  • Sensing Technology

Background:

  • Refractive index (RI) sensing is crucial for industrial metrology, biochemical detection, and environmental analysis.
  • Optofluidic RI sensors combine microoptics and microfluidics, offering label-free and non-invasive detection.
  • Existing optofluidic RI sensors require improvements in sensitivity, detection range, fabrication, and cost.

Purpose of the Study:

  • To fabricate a novel 3D-cascade-microlens optofluidic chip (3DCMOC) for enhanced refractive index sensing.
  • To demonstrate adjustable sensitivity and tunable detection ranges for diverse sensing applications.
  • To validate the chip's performance in real-world scenarios like salinity and urine specific gravity analysis.

Main Methods:

  • Fabrication of the 3DCMOC using two-photon stereolithography for mold creation, followed by mold replication.
  • Integration of four detection channels with varying numbers of cascaded microlenses (1, 3, 5, 7).
  • Characterization of RI sensing performance using standard sucrose solutions and real-time environmental samples.

Main Results:

  • The seven-microlens configuration achieved high sensitivity (21 ± 5 AU·RIU⁻¹) and resolution (3.8 × 10⁻⁵ RIU) over a narrow range (1.3326-1.3548).
  • The single-microlens configuration provided lower sensitivity (2.6 ± 0.2 AU·RIU⁻¹) and resolution (1.5 × 10⁻⁴ RIU) but a wider linear dynamic range (1.3326-1.5120).
  • The 3DCMOC successfully performed real-time salinity sensing and urine specific gravity analysis.

Conclusions:

  • The 3DCMOC offers a versatile platform for refractive index sensing with tunable performance.
  • The design allows for a trade-off between sensitivity and detection range, catering to specific application needs.
  • This technology shows promise for practical applications in environmental monitoring and biochemical analysis.