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Troponin T in COVID-19 hospitalized patients: Kinetics matter

Maria-Luiza Luchian1, Andreea Iulia Motoc2, Stijn Lochy2

  • 1Department of Cardiology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, (Centrum voor Hart- en Vaatziekten), Brussels, Belgium. marialuiza.luchian@yahoo.com.

Cardiology Journal
|September 28, 2021
PubMed

Insights

Elevated cardiac troponin T (cTn T) levels and their trends predict major adverse cardiovascular events (MACE) and mortality in COVID-19 patients. cTn T testing aids in risk stratification and management of these patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) poses a significant threat to global health.
  • Elevated cardiac troponin T (cTn T) levels upon admission correlate with increased in-hospital mortality.
  • Limited data exists on the predictive value of cTn T kinetics for major adverse cardiovascular events (MACE) in COVID-19 patients.

Purpose of the Study:

  • To investigate the role of baseline cTn T levels and cTn T kinetics in predicting MACE and in-hospital mortality in COVID-19 patients.

Main Methods:

  • Prospective study including 202 COVID-19 patients.
  • Patients categorized by cTn T kinetics: ascending, descending, or constant.
  • cTn T slope calculated as the ratio of cTn T change over time.

Main Results:

  • Baseline cTn T levels significantly predicted both MACE and mortality.
  • An increased cTn T slope was associated with higher mortality.
  • Constant cTn T levels correlated with lower rates of MACE and mortality.

Conclusions:

  • cTn T testing provides valuable prognostic information in COVID-19.
  • Monitoring cTn T kinetics aids in risk stratification and guides patient management.
  • This approach can improve the diagnostic pathway for COVID-19 patients at risk for cardiovascular complications.
Abstract

Keywords:
COVID-19cardiac troponinkineticsmajor cardiovascular adverse eventsmortalitymyocardial injury

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