Related Experiment Video
Updated: Oct 18, 2025

Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
Published on: April 23, 2012
Biosynthesis of the Fusarium Mycotoxin (-)-Sambutoxin
Eun Bin Go1, Lee Joon Kim1, Hosea M Nelson1,2
1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Abstract:
4-Hydroxy-2-pyridone alkaloids have attracted attention for synthetic and biosynthetic studies due to their broad biological activities and structural diversity. Here, we elucidated the pathway and chemical logic of (-)-sambutoxin (1) biosynthesis. In particular, we uncovered the enzymatic origin of the tetrahydropyran moiety and showed that the p-hydroxyphenyl group is installed via a late-stage, P450-catalyzed oxidation of the phenylalanine-derived side chain rather than via a direct incorporation of tyrosine.
More Related Videos
08:19Toxin Induction and Protein Extraction from Fusarium spp. Cultures for Proteomic Studies
Published on: February 16, 2010
09:21Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
Related Concept Videos
Fungal Phylum Basidiomycota
Fungal Phylum Ascomycota
Fungal Group Zygomycota
Sulfur Assimilation