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EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

Parashar Thapa1, Robert Stewart1, Rebecka J Sepela1

  • 1Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA.

The Journal of General Physiology
|September 28, 2021
PubMed
Summary

Researchers developed EVAP (Endogenous Voltage-sensor Activity Probe), a novel imaging tool to measure conformational changes in voltage sensors of endogenous ion channel proteins within live tissue. This method visualizes Kv2 protein dynamics in neurons without genetic modification.

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