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Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification

Andrew B Morgenthaler1, Ryan K Fritts1, Shelley D Copley1

  • 1Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA.

Molecular Biology and Evolution
|September 28, 2021
PubMed
Summary

Gene duplications drive enzyme evolution, but surrounding genes must be removed. This study shows amplicon remodeling can occur before mutations, leading to complex population dynamics and diverse fitness improvements in evolving enzymes.

Keywords:
ProAamplicon remodelinggene duplication and divergencemolecular evolution

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