Advances in aptamer-based sensing assays for C-reactive protein

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Molecular Diagnostics

Background:

• C-reactive protein (CRP) is a key indicator of inflammation in clinical diagnostics.
• Rapid advancements in testing technologies are enabling faster, simpler, and more reliable CRP detection methods.
• Aptamer-based biosensors are emerging as a promising technology for high-sensitivity CRP analysis.

Purpose of the Study:

• To review the progress in in vitro aptamer screening specifically for C-reactive protein (CRP).
• To summarize recent advancements in the application of aptamer-based biosensors for CRP detection.
• To provide insights for developing novel aptasensor design strategies for CRP.

Main Methods:

• Review of literature on in vitro aptamer selection techniques.
• Analysis of recent studies on aptamer-based biosensor development for CRP.
• Synthesis of findings to identify trends and future directions in CRP aptasensor design.

Main Results:

• Significant progress has been made in aptamer screening methodologies for CRP.
• Various aptamer-based biosensors have demonstrated high sensitivity and specificity for CRP detection.
• Current research focuses on enhancing the performance and clinical applicability of CRP aptasensors.

Conclusions:

• Aptamer-based biosensors represent a powerful tool for sensitive and specific CRP detection.
• Continued research in aptamer screening and sensor engineering will drive innovation in CRP diagnostics.
• This review provides a foundation for designing next-generation CRP aptasensors with improved diagnostic capabilities.