Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Epidermis01:24

Cells of the Epidermis

5.5K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
5.5K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.7K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.7K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.9K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.9K
Reticular Dermis01:15

Reticular Dermis

3.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biodegradable Polyester-Starch Composite Films Functionalized with Phenolic Compounds: Advances, Challenges, and Prospects for Sustainable Active Packaging.

Polymers·2026
Same author

From leaf to cellulose scaffold: Decellularization and multi-scale characterization of <i>Neolamarckia cadamba</i> leaf for biomedical applications.

Journal of biomaterials applications·2026
Same author

Isolation, genomic characterization, and biofilm eradication activity of vB_PaP_DMTU_1, a novel lytic bacteriophage against Pseudomonas aeruginosa.

Folia microbiologica·2026
Same author

Biopolymer coatings for barrier and functional enhancement of sustainable food packaging: Recent advances and emerging trends.

International journal of biological macromolecules·2026
Same author

Unleashing the immune arsenal: development of broad spectrum multiepitope bluetongue vaccine targeting conserved T cell epitopes of structural proteins.

BMC genomics·2026
Same author

Development of a high-copy target enhanced multiplexed crRNA-based, amplification-free detection assay (HiTECT) for Brucella spp.

Molecular biology reports·2026
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Oct 18, 2025

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

16.2K

Decellularization of Skin Tissue.

Naveen Kumar1, Vineet Kumar2, Sanjay Purohit2

  • 1Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, India. naveen.ivri1961@gmail.com.

Advances in Experimental Medicine and Biology
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

Naturally derived biomaterials, like decellularized extracellular matrix (ECM), offer superior biocompatibility and biodegradability for tissue repair. Their structural similarity to native tissues enhances cell integration and promotes regeneration, making them promising for medical applications.

Keywords:
DecellularizationDermal MatrixSkinTissue engineering

More Related Videos

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

11.5K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.7K

Related Experiment Videos

Last Updated: Oct 18, 2025

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

16.2K
Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

11.5K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.7K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Biomaterials are engineered to interact with biological systems for therapeutic purposes.
  • Natural-derived biomaterials, particularly decellularized extracellular matrix (ECM), are gaining focus due to their inherent advantages.
  • ECM scaffolds from xenografts or allografts mimic native tissue structure and composition.

Purpose of the Study:

  • To review the development of natural and synthetic dermal matrices.
  • To highlight advancements in biomaterials for tissue repair and regeneration.
  • To discuss the advantages of naturally derived biomaterials over synthetic alternatives.

Main Methods:

  • Focus on decellularized extracellular matrix (ECM) from animal or human sources.
  • Analysis of biomaterial properties including biocompatibility, biodegradability, and remodeling.
  • Review of cell interaction with ECM, including adhesion, migration, proliferation, and differentiation.

Main Results:

  • Naturally derived biomaterials exhibit excellent biocompatibility, biodegradability, and remodeling properties.
  • ECM scaffolds support cell adhesion, migration, proliferation, and differentiation.
  • These materials effectively induce tissue repair by promoting cell attachment and migration.

Conclusions:

  • Naturally derived biomaterials offer significant advantages for tissue and organ replacement or restoration.
  • ECM's structural and biological resemblance to native tissues facilitates superior integration and function.
  • Continued research into natural and synthetic dermal matrix development is crucial for advancing regenerative medicine.