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Updated: Oct 18, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.4K

Emerging roles of Sirtuin 2 in cardiovascular diseases

Arushi Taneja1, Venkatraman Ravi1, Jun Young Hong2

  • 1Department of Microbiology and Cell Biology, Cardiovascular and Muscle Research Laboratory, Indian Institute of Science, Bengaluru, India.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|September 28, 2021
PubMed

Insights

Sirtuin 2 (SIRT2) levels decrease in the heart with aging and disease, contributing to cardiovascular dysfunction. Understanding SIRT2

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Aging Research

Background:

  • Sirtuins are NAD+-dependent deacetylases linked to age-associated diseases.
  • SIRT2 regulates cellular processes via protein deacetylation.
  • Declining SIRT2 levels in the heart correlate with cardiovascular dysfunction.

Purpose of the Study:

  • To review the emerging roles of SIRT2 in cardiovascular dysfunction.
  • To explore SIRT2's involvement in age, hypertension, oxidative stress, and diabetes-related heart issues.
  • To discuss the utility of SIRT2 inhibitors in cardiac research.

Main Methods:

  • Literature review of studies on SIRT2 and cardiovascular health.
  • Analysis of SIRT2's deacetylation targets and pathways.
  • Discussion of pathological conditions affecting cardiac SIRT2 levels.

Main Results:

  • SIRT2 decline is associated with heart failure and dysfunction.
  • Factors like aging, hypertension, oxidative stress, and diabetes impact cardiac SIRT2.
  • SIRT2 modulation affects various cellular processes relevant to heart health.

Conclusions:

  • SIRT2 plays a significant, yet incompletely understood, role in the cardiovascular system.
  • Further research into SIRT2's cardiac functions is warranted.
  • SIRT2 presents a potential therapeutic target for cardiovascular diseases.
Keywords:
SIRT2Sirtuinscardiac hypertrophycardiovascular diseasesoxidative stress

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