Related Experiment Video

Updated: Oct 18, 2025

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
06:23

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

15.1K

Uncloaking tumors

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|September 28, 2021
PubMed

Insights

Blocking poly (ADP-ribose) polymerase 7 (PARP7) activates an antiviral pathway that helps the immune system detect and attack cancer. This discovery opens new avenues for cancer immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Poly (ADP-ribose) polymerase 7 (PARP7) is an enzyme involved in DNA repair and other cellular processes.
  • Cancer cells often evade immune detection through various mechanisms.
  • Antiviral pathways are crucial for innate immunity and can be co-opted for therapeutic benefit.

Purpose of the Study:

  • To investigate the role of PARP7 in cancer immunosurveillance.
  • To determine if blocking PARP7 can enhance anti-cancer immune responses.
  • To explore the potential of targeting PARP7 as a cancer immunotherapy strategy.

Main Methods:

  • Utilized genetic and pharmacological inhibition of PARP7 in cancer models.
  • Assessed immune cell activation and infiltration in tumors.
  • Analyzed the induction of antiviral-associated gene expression.

Main Results:

  • Inhibition of PARP7 led to the activation of an intrinsic antiviral-associated signaling pathway.
  • Blocking PARP7 enhanced the recruitment and activation of immune cells within the tumor microenvironment.
  • PARP7-deficient tumors exhibited increased susceptibility to immune-mediated destruction.

Conclusions:

  • PARP7 acts as a negative regulator of cancer immunosurveillance.
  • Targeting PARP7 can unleash a potent antiviral-associated immune response against cancer.
  • Blocking PARP7 represents a promising novel strategy for cancer immunotherapy.

More Related Videos

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment08:24

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

Published on: June 12, 2016

8.3K
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models06:57

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Published on: April 7, 2018

11.1K

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.6K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.8K