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Multiorgan Infarctions in a Young Adult with COVID-19: Autopsy Findings

Fazilet Yilmaz1, Weibiao Cao2

  • 1Department of Pathology and Laboratory Medicine, Rhode Island Hospital and The Alpert Medical School of Brown University, Providence, RI.

Rhode Island Medical Journal (2013)
|September 28, 2021
PubMed

Insights

Young patients with COVID-19 can experience severe blood clots and organ damage, even with preventative anticoagulation. This case highlights rare multiorgan infarctions in a 35-year-old male with diabetes, emphasizing the critical risks of SARS-CoV-2 infection.

Area of Science:

  • Cardiology
  • Nephrology
  • Neurology

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and thrombotic events.
  • Multiorgan infarctions are exceptionally rare complications, particularly in younger individuals.

Observation:

  • A 35-year-old male with uncontrolled diabetes was admitted to the ICU for SARS-CoV-2 infection and hypoxia.
  • Despite prophylactic anticoagulation, the patient suffered hypoxic respiratory arrest, anoxic brain injury, and brain herniation.

Findings:

  • Postmortem examination revealed extensive infarctions and thromboses in the heart, lungs, kidneys, and spleen.
  • This indicates severe thrombotic complications of COVID-19 affecting multiple organs.

Implications:

  • Multiorgan infarctions can occur in young COVID-19 patients, even with prophylactic anticoagulation.
  • Highlights the need for vigilant monitoring and potentially aggressive anticoagulation strategies in high-risk COVID-19 patients.
  • Underscores the severe systemic impact of SARS-CoV-2 infection beyond respiratory symptoms.

Keywords:
COVID-19heartinfarctionkidneylungmultiple organsspleen

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