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ST-Elevation Myocardial Infarction Patients with Hyperglycemia: Effects of Intravenous Adenosine

Pasquale Mone1, Antonella Pansini2, Mario Rizzo3

  • 1Department of Medicine, University of the Study of Campania "Luigi Vanvitelli", Naples, Italy; Azienda Sanitaria Locale Avellino, Avellino, Italy.

The American Journal of the Medical Sciences
|September 28, 2021
PubMed

Insights

Intravenous adenosine infusion during primary percutaneous coronary intervention (PPCI) significantly reduced mortality and re-hospitalizations in hyperglycemic patients with ST-segment elevation myocardial infarction (STEMI). Further research is needed to confirm these findings.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Admission hyperglycemia is prevalent in acute myocardial infarction (AMI) patients.
  • Primary percutaneous coronary intervention (PPCI) is the standard reperfusion therapy for ST-segment elevation myocardial infarction (STEMI).
  • Despite PPCI, mortality and re-hospitalizations remain significant challenges.

Purpose of the Study:

  • To investigate the effects of intravenous adenosine combined with PPCI.
  • To assess outcomes in hyperglycemic STEMI patients receiving adenosine infusion.

Main Methods:

  • Evaluated 399 hyperglycemic STEMI patients (glycemia >140 mg/dL).
  • Patients were divided into two groups: those receiving intravenous adenosine with PPCI (199 patients) and those receiving PPCI alone (200 patients).

Main Results:

  • Kaplan-Meier analysis revealed significant reductions in all-cause death, cardiac death, and re-hospitalizations for heart failure and acute coronary syndrome in the adenosine-treated group.
  • The study included 199 patients who received adenosine and PPCI, and 200 who did not.

Conclusions:

  • Intravenous adenosine infusion in addition to PPCI shows significant positive effects on clinical outcomes in hyperglycemic STEMI patients.
  • Larger studies with extended follow-up are required to validate these promising results.
Abstract

Keywords:
AdenosineHyperglycemiaSTEMI

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