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Related Concept Videos

Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.4K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
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Additional Subnuclear Structures02:10

Additional Subnuclear Structures

4.8K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
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Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

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The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
3.0K
The Nucleus01:32

The Nucleus

96.9K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
96.9K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

2.6K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.6K
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

5.2K
Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
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The centriculum, a membrane reticulum that surrounds Caenorhabditis elegans centrosomes, might serve as a microtubule filter.

Journal of cell science·2026
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Kar4 acts as a Ste12 regulator in Saccharomyces cerevisiae, promoting Ste12 binding to a specific DNA motif genome-wide.

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Kar4 acts as a Ste12 regulator in <i>Saccharomyces cerevisiae</i>, promoting Ste12 binding to a specific DNA motif genome-wide.

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The centriculum, a membrane that surrounds <i>C. elegans</i> centrosomes, acts as a microtubule filter.

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A membrane reticulum, the centriculum, affects centrosome size and function in Caenorhabditis elegans.

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Related Experiment Video

Updated: Oct 18, 2025

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
06:54

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

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Cell biology: How does the nucleus get its membrane?

Orna Cohen-Fix1

  • 1The Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA.

Current Biology : CB
|September 28, 2021
PubMed
Summary

Nuclear membrane availability impacts cell shape and fate. A new study shows the nuclear membrane originates from the endoplasmic reticulum, revealing a key process in cell division.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Nuclear envelope formation and maintenance are crucial for eukaryotic cell function.
  • The precise mechanisms linking nuclear membrane availability to nuclear shape, size, and cell fate remain incompletely understood.

Purpose of the Study:

  • To investigate the source of nuclear membrane during cell division.
  • To explore the functional consequences of limiting nuclear membrane expansion on cell fate determination.

Main Methods:

  • Utilized live-cell imaging techniques to observe nuclear envelope dynamics.
  • Employed genetic manipulation to control endoplasmic reticulum-derived membrane supply.
  • Analyzed cell morphology and differentiation markers in response to altered nuclear membrane availability.

More Related Videos

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

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Related Experiment Videos

Last Updated: Oct 18, 2025

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

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Main Results:

  • Demonstrated that the nuclear membrane is primarily derived from the endoplasmic reticulum.
  • Showed that restricting nuclear membrane expansion during asymmetric cell division leads to altered cell fates.
  • Established a direct link between nuclear membrane dynamics and the regulation of cell differentiation.

Conclusions:

  • The endoplasmic reticulum serves as the direct source for the expanding nuclear envelope.
  • Nuclear membrane availability is a critical regulatory factor influencing cell fate decisions during development.
  • Understanding this process offers insights into developmental abnormalities and potential therapeutic targets.