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Low Creatininuria due to Hyponatremia Is Reversible in Many Patients
Guy Decaux1,2
1Department of Internal Medicine, Hôpital Erasme, Brussels, Belgium.
Nephron
|September 28, 2021
Summary
Long-term correction of chronic hyponatremia in SIADH patients reversed low solute and creatinine excretion, indicating improved muscle health and metabolic function. These metabolic changes are reversible with treatment.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Chronic hyponatremia is linked to reduced solute intake and creatinine excretion, suggesting sarcopenia.
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a common cause of euvolemic hyponatremia.
Purpose of the Study:
- To investigate the long-term effects of hyponatremia correction on solute and creatinine excretion in patients with chronic SIADH.
- To determine if metabolic abnormalities associated with chronic hyponatremia are reversible.
Main Methods:
- Retrospective review of clinical and biochemical data.
- Analysis of 24-hour urine solute and creatinine excretion in patients with chronic SIADH before and after treatment.
- Comparison with healthy volunteers with induced hyponatremia.
Main Results:
- Confirmed low urine creatinine and solute excretion in chronic hyponatremia (>1 month).
- Long-term correction (3 months) of hyponatremia increased 24-hour creatinine excretion (p < 0.02) and solute excretion with vaptan treatment (p < 0.02).
- Sodium excretion also significantly increased post-correction (p < 0.01).
Conclusions:
- Chronic hyponatremia is associated with decreased solute and creatinine excretion.
- These metabolic abnormalities are reversible with long-term correction of hyponatremia.
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