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Updated: Oct 18, 2025

A Preclinical Model of Exertional Heat Stroke in Mice

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Extreme hyperthermia-induced arrhythmogenesis.

Tripat Kaur¹, Chenni S Sriram², Utkarsh Kohli^1,3,4,5

¹Department of Pediatrics, Comer Children's Hospital, Chicago, IL, USA.

Cardiology in the Young

|September 29, 2021

Summary

This summary is machine-generated.

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Severe hyperthermia can cause dangerous heart rhythm problems. Prompt cooling is crucial for treating life-threatening ventricular tachycardia induced by high body temperature.

Area of Science:

Cardiology
Pediatrics
Thermoregulation

Background:

Hyperthermia, or elevated body temperature, impairs heat regulatory mechanisms.
It significantly impacts cardiovascular function.
Life-threatening arrhythmias can occur during hyperthermia.

Purpose of the Study:

To report a case of hyperpyrexia-induced ventricular tachycardia.
To highlight the effectiveness of cooling in refractory cases.
To emphasize the importance of immediate cooling in pediatric hyperthermia.

Main Methods:

Case report of a 6-year-old girl.
Management of hyperpyrexia and ventricular tachycardia.
Therapeutic hypothermia as an intervention.

Keywords:

Extreme hyperthermia arrhythmogenesis ventricular tachycardia

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Main Results:

The patient presented with ventricular tachycardia due to severe hyperthermia.
The arrhythmia was refractory to standard treatments like cardioversion and anti-arrhythmics.
Rapid and aggressive cooling led to prompt resolution of the tachycardia.

Conclusions:

Hyperthermia can precipitate severe cardiac arrhythmias, including ventricular tachycardia.
Aggressive and immediate cooling is a critical, potentially life-saving intervention.
This case underscores the importance of recognizing and managing hyperthermia-induced cardiovascular complications in children.