Related Experiment Video
Updated: Oct 18, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Extreme hyperthermia-induced arrhythmogenesis
Tripat Kaur1, Chenni S Sriram2, Utkarsh Kohli1,3,4,5
1Department of Pediatrics, Comer Children's Hospital, Chicago, IL, USA.
Abstract:
Hyperthermia is defined as an elevated body temperature above the normal range due to a failure of heat regulatory mechanisms. In addition to its effects on other organ systems, hyperthermia is associated with profound cardiovascular effects. We report the sentinel case of a 6-year-old girl with structurally and electrically normal heart, who presented with life-threatening hyperpyrexia-induced ventricular tachycardia, which was refractory to cardioversion and anti-arrhythmics but responded promptly to cooling. We emphasise the lifesaving role of immediate and aggressive cooling in such patients.
More Related Videos
08:28Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
08:22In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Related Concept Videos
Homeostatic Imbalances in Body Temperature
Mechanism of Cardiac Arrhythmias
Increased Body Temperature
Dysrhythmias III: Characteristics of Dysrhythmias
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias II: Classification of Tachyarrhythmias