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Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional

Thom O'Neill1, Peter M Gillett2, Philippa Wood1

  • 1Paediatric Department, Royal Hospital for Children and Young People, Edinburgh, UK.

Archives of Disease in Childhood
|September 29, 2021
PubMed

Insights

Neurological problems affect 28% of children with coeliac disease (CD), with later diagnosis and male gender being risk factors. Prevalence is lower than in adults and similar to the general child population.

Area of Science:

  • Pediatric Neurology
  • Gastroenterology
  • Epidemiology

Background:

  • Neurological complications in childhood coeliac disease (CD) are not well understood.
  • Existing research primarily focuses on adult CD populations.

Purpose of the Study:

  • To determine the prevalence of neurological problems in children diagnosed with CD.
  • To identify potential risk factors associated with these neurological issues.

Main Methods:

  • A cross-sectional, community-based audit was conducted.
  • Data were collected from children diagnosed with CD between January 2010 and December 2016 in Lothian.
  • Prevalence and risk factors for neurological problems were analyzed.

Main Results:

  • 28% (79/284) of children with CD experienced neurological problems.
  • Headaches/migraine (5.3%) and anxiety (3.5%) were the most common issues.
  • Later age at CD diagnosis and male gender were associated with increased risk.

Conclusions:

  • The prevalence of neurological problems in pediatric CD is lower than reported in adult studies.
  • Findings suggest a similar or lower prevalence compared to the general childhood population.
  • Highlights the importance of monitoring neurological health in children with CD.
Abstract

Keywords:
epidemiologygastroenterologyneurology

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