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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Managing Active Iupus Nephritis During COVID-19 Pandemic
Joyita Bharati1, Manish Rathi1, Raja Ramachandran1
1Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian Journal of Nephrology
|September 29, 2021
Summary
This study shows that patients with lupus nephritis (LN) can be safely treated with strong immunosuppression during the COVID-19 pandemic. Hydroxychloroquine and precautions may offer protection against COVID-19 in these patients.
Area of Science:
- Immunology
- Nephrology
- Infectious Diseases
Background:
- The COVID-19 pandemic raised concerns about managing immunosuppressed patients, particularly those with lupus nephritis (LN).
- Understanding the risks associated with intense immunosuppression in LN patients during a pandemic is crucial.
Observation:
- Thirteen active lupus nephritis patients managed with intense immunosuppression during the COVID-19 pandemic were observed.
- All patients received hydroxychloroquine as standard care, with strict infection prevention measures implemented.
Findings:
- No patients developed COVID-19; one experienced acute respiratory distress syndrome but tested negative.
- This suggests that intense immunosuppression can be safely administered to LN patients during the pandemic with appropriate precautions.
Implications:
- The findings support the safe management of active lupus nephritis patients with immunosuppression during the COVID-19 pandemic.
- Further research is warranted to explore the protective role of hydroxychloroquine and precautions against COVID-19 in systemic lupus erythematosus patients.
Keywords:
COVID-19flarehydroxychloroquineimmunosuppressionlupus nephritissystemic lupus erythematosusMore Related Videos
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