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Injection Cryolipolysis: First-in-human Study.

Prasanthi Kandula1, Emilia Javorsky2, William G Austen3

  • 1Skin Care Physicians, Chestnut Hill, Mass.

Plastic and Reconstructive Surgery. Global Open
|September 29, 2021
PubMed
Summary
This summary is machine-generated.

Injection cryolipolysis using ice slurry is a feasible new method for fat reduction. This pilot study found it safe and tolerable, showing evidence of fat cell destruction in treated areas.

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Area of Science:

  • Aesthetic medicine
  • Dermatology
  • Medical technology

Background:

  • Injection cryolipolysis with ice slurry is a novel, hypothesized method for fat reduction.
  • This pilot study investigates the feasibility, safety, and tolerability of injecting ice slurry into human subcutaneous fat.

Purpose of the Study:

  • To assess the feasibility of ice slurry injection for fat reduction.
  • To evaluate the safety and tolerability of this novel cryolipolysis technique.
  • To observe the effects of ice slurry injection on subcutaneous fat tissue.

Main Methods:

  • Pilot study involving preabdominoplasty subjects receiving single ice slurry injections.
  • Control group received melted ice slurry injection.
  • Assessed feasibility, safety (adverse events), tolerability (pain scores), and used thermal imaging, ultrasound, and histology to monitor effects.

Main Results:

  • Ice slurry injection was feasible and effectively cooled adipose tissue below 10°C.
  • No serious adverse events occurred; common events were bruising and erythema.
  • Ultrasound and histology confirmed cryolipolysis in ice slurry-treated sites, with minimal effects in control sites.

Conclusions:

  • Ice slurry injections are feasible with a safety and tolerability profile similar to topical cryolipolysis.
  • The technique effectively induces cryolipolysis, selectively targeting injected areas.
  • Ice slurry shows promise for precise, effective, and customizable aesthetic fat reduction, warranting further research.