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Maternal hyperoxygenation in congenital heart disease
Fu-Tsuen Lee1,2, Davide Marini2, Mike Seed2,3
1Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada.
Translational Pediatrics
|September 29, 2021
Summary
Maternal hyperoxygenation (MH) shows promise in diagnosing and treating congenital heart disease (CHD) in fetuses. This approach may improve fetal heart and brain development, particularly for left-sided cardiac defects.
Area of Science:
- Cardiology
- Fetal Medicine
- Medical Imaging
Background:
- Congenital heart disease (CHD) poses significant risks to fetal morbidity and mortality.
- Advancements in medical imaging improve understanding and assessment of CHD.
- Left-sided heart lesions are a key focus for improving fetal outcomes.
Purpose of the Study:
- To review the diagnostic and therapeutic applications of maternal hyperoxygenation (MH) in fetal CHD.
- To assess the impact of MH on fetal heart and brain development.
- To evaluate the utility of acute and chronic MH administration in managing left-sided cardiac defects.
Main Methods:
- Review of studies investigating maternal hyperoxygenation (MH) in fetal CHD.
- Analysis of MH as a diagnostic tool for pulmonary vasculature assessment.
- Evaluation of MH as a therapeutic agent for improving fetal cardiac and cerebral development.
Main Results:
- MH has been explored for a decade as both a diagnostic and therapeutic strategy in fetal CHD.
- Disrupted fetal hemodynamics in left-sided lesions contribute to progressive left ventricle underdevelopment.
- MH may positively impact fetal brain growth and potentially lung development.
Conclusions:
- Maternal hyperoxygenation (MH) is a promising intervention for fetuses with CHD, especially left-sided defects.
- MH can aid in assessing pulmonary vasculature and improving fetal cardiac and brain development.
- Further understanding of acute and chronic MH administration is crucial for optimizing fetal outcomes in CHD.
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