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14q+ in Ph-positive chronic myelogenous leukemia
Cancer Genetics and Cytogenetics
|July 1, 1986
Summary
Two chronic myelogenous leukemia cases with Philadelphia chromosome translocation and additional 14q+ changes are presented. One patient experienced myeloid blastic crisis, indicating a potential prognostic marker.
Area of Science:
- Hematology
- Cytogenetics
- Oncology
Background:
- Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm characterized by the Philadelphia chromosome (Ph).
- Additional chromosomal abnormalities can occur in CML and may influence disease progression.
Observation:
- Two CML patients with Ph translocation and an additional 14q+ abnormality were analyzed.
- Breakpoints on chromosome 14 were localized to 14q24 and 14q32 in the reported cases.
Findings:
- One patient presented without blastic transformation.
- The second patient developed a myeloid blastic crisis, coinciding with the detection of the abnormal 14q+ marker in bone marrow cells.
Implications:
- The 14q+ abnormality may be associated with disease progression in CML.
- Further research is needed to clarify the prognostic significance of 14q+ in Philadelphia chromosome-positive leukemia.