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A case of COVID-19 vaccination-associated forme fruste purpura fulminans

J Griss1, S Eichinger2, S Winkler3

  • 1Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria.

The British Journal of Dermatology
|September 29, 2021
PubMed

Insights

A 77-year-old patient developed skin infarctions after receiving the Moderna COVID-19 vaccine (mRNA-1273). This rare vascular event, distinct from purpura fulminans, highlights the need for vigilance regarding vaccine-related side effects.

Area of Science:

  • Dermatology
  • Immunology
  • Vascular Medicine

Background:

  • The mRNA-1273 vaccine (Moderna) is a widely used COVID-19 vaccine.
  • Skin infarctions are typically associated with severe conditions like purpura fulminans.

Observation:

  • A 77-year-old female patient presented with multi-localized skin infarctions.
  • The onset of skin infarctions occurred post-vaccination with mRNA-1273.

Findings:

  • Infection-associated purpura fulminans was ruled out in this patient.
  • The observed skin infarctions represent a rare vascular phenomenon potentially linked to mRNA-1273 vaccination.

Implications:

  • This case suggests a broader spectrum of potential vascular side effects associated with COVID-19 mRNA vaccinations.
  • Healthcare providers should maintain vigilance for unusual vascular events following vaccination.
  • Further research is warranted to understand the mechanisms and incidence of such reactions.

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