Low Serum Testosterone Levels in Male Patients with Type 2 Diabetes Mellitus as a Risk Factor for Coronary Artery
Manoj Saluja1, Vishwas Galav2, Drishya Pillai3
1Senior Professor, Government Medical College, Kota, Rajasthan.
Background:
Diabetes mellitus is a chronic debilitating illness associated with several complications of which hypogonadism in male patients with type 2 diabetes mellitus (T2DM) is often overlooked but carries a high prevalence and possibly associated with several co-morbidities.
Objectives:
To study the correlation of serum testosterone with clinical and biochemical factors in male patients with type 2 diabetes mellitus.
Method:
In our cross-sectional study, we selected a group of 100 patients with type 2 diabetes mellitus (50 each with hypogonadism and 50 with eugonadism) and obtained their biochemical parameters and looked for the prevalence of co-morbid conditions. We did a correlation of serum testosterone with each quantitative variable using Pearson's Coefficient of correlation and multivariable logistic regression analysis was applied.
Result:
Serum testosterone levels were found to be correlated with age, waist circumference, fasting blood sugar, serum triglycerides and eGFR (p<0.05).The prevalence of coronary artery disease was higher in T2DM male patients with hypogonadism as compared eugonadal patients. We found higher odds (1.33 times) for coronary artery disease in male patients with hypogonadism and T2DM as compared to males with T2DM and eugonadism.
Conclusion:
There is a higher risk of coronary artery disease in male patients with T2DM and hypogonadism as compared to males with T2DM and eugonadal status.
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