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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Recent Progress in Polymeric AIE-Active Drug Delivery Systems: Design and Application
Yang Pei1, Ziyu Wang2, Cheng Wang3,4
1School of History, Nanjing University, Nanjing, Jiangsu 210023, People's Republic of China.
Molecular Pharmaceutics
|September 29, 2021
Summary
Polymeric aggregation-induced emission (AIE) materials offer advanced drug delivery systems (DDSs) for imaging-guided therapy. These AIEgens enable precise cancer treatment, antibacterial applications, and monitoring of drug delivery effectiveness.
Area of Science:
- Materials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Traditional fluorophores suffer from aggregation-induced quenching, limiting their applications.
- Aggregation-induced emission (AIE) offers a solution by exhibiting strong fluorescence upon aggregation.
- AIEgens are increasingly utilized in advanced applications like drug delivery systems (DDSs).
Purpose of the Study:
- To review the design and applications of polymeric AIE-active DDSs.
- To highlight the advantages of AIEgens in overcoming traditional limitations.
- To showcase the potential of these materials in various therapeutic areas.
Main Methods:
- Summarizing synthetic strategies for AIE-active polymers.
- Discussing responsive strategies for targeted drug delivery.
- Compiling examples of AIE-based DDSs for different applications.
Main Results:
- Polymeric AIE-active DDSs demonstrate ease of fabrication and tunable optical properties.
- These systems facilitate imaging-guided therapy and pharmacodynamic monitoring.
- Successful applications in cancer therapy and antibacterial treatments were observed.
Conclusions:
- Polymeric AIE-active DDSs represent a significant advancement in biomedical applications.
- Their tunable nature and fluorescence properties make them ideal for targeted therapies.
- Further development holds great promise for improving disease treatment efficacy.
Keywords:
AIE-active polymeraggregation-induced emissionbacterial treatmentcancer therapydrug delivery monitoringdrug delivery systempeacebuildingMore Related Videos
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