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Filgotinib as rheumatoid arthritis therapy.

A Becciolini1, E Di Donato2, D Santilli2

  • 1Department of Medicine, Internal Medicine and Rheumatology Unit, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. beccio@yahoo.it.

Drugs of Today (Barcelona, Spain : 1998)
|September 29, 2021
PubMed
Summary

Filgotinib, a selective JAK1 inhibitor, offers a new oral treatment option for rheumatoid arthritis (RA) patients who do not respond well to other therapies. Studies confirm its safety and effectiveness in managing RA symptoms.

Keywords:
Autoimmune disordersFilgotinibJanus kinase 1 (JAK1) inhibitorsMusculoskeletal and connective tissue disordersRheumatoid arthritisTyrosine kinase inhibitors

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Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune condition causing joint inflammation and disability.
  • A significant portion of RA patients (up to 30%) show inadequate response or lose response to existing treatments like conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and biological DMARDs (bDMARDs).
  • Janus kinase inhibitors (JAKis) represent a newer class of drugs for RA management.

Purpose of the Study:

  • To evaluate the safety and efficacy of filgotinib, a selective JAK1 inhibitor, in treating rheumatoid arthritis (RA).
  • To assess filgotinib's utility in RA patients with inadequate response to prior therapies.

Main Methods:

  • Clinical trials (Phase II and III) were conducted to assess filgotinib.
  • Studies included RA patients who were naive to DMARDs or had an insufficient response to csDMARDs and bDMARDs.
  • Filgotinib was administered orally.

Main Results:

  • Phase II and III studies demonstrated the safety and efficacy of filgotinib in RA patients.
  • The drug showed positive outcomes in patients with varying treatment histories, including those new to DMARDs and those who had failed other treatments.

Conclusions:

  • Filgotinib is an effective and safe oral treatment option for rheumatoid arthritis.
  • It provides a valuable therapeutic alternative for RA patients with inadequate response to conventional and biologic therapies.
  • Recommended dosages are 200 mg daily, with a reduced dose of 100 mg daily for patients over 75 or with moderate to severe renal impairment.