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Ocular surface toxicity of depatuxizumab mafoditin (ABT-414): case reports

Carlos Rocha-de-Lossada1, Carmen Alba Linero1, Álvaro Santos Ortega1

  • 1Ophthalmology Department, Hospital Regional Universitario de Málaga, Málaga, Spain.

Arquivos Brasileiros De Oftalmologia
|September 29, 2021
PubMed

Insights

Depatuxizumab mafoditin (ABT-414) therapy for glioblastoma can cause temporary ocular surface toxicity, including keratitis and blurred vision. Symptoms resolved within four weeks with artificial tears and lubricant ointment.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Glioblastoma multiforme is an aggressive brain tumor.
  • Depatuxizumab mafoditin (ABT-414) is an investigational antibody-drug conjugate targeting EGFR. It is used in treating unresectable glioblastoma.

Observation:

  • Three patients receiving ABT-414 for glioblastoma experienced ocular surface toxicity.
  • Ocular symptoms including keratitis, decreased visual acuity, blurred vision, foreign-body sensation, and redness appeared within a week of the first infusion.

Findings:

  • The ocular toxicity was mild-to-moderate and transient, with symptoms and visual acuity improving within four weeks.
  • Artificial tears and lubricant ointment were sufficient to manage the ocular surface signs and symptoms.

Implications:

  • ABT-414 therapy may induce transient ocular surface toxicity.
  • Ophthalmologic monitoring and established management protocols are crucial for patients undergoing ABT-414 treatment.

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