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Related Concept Videos

ABC Transporters: Exporter01:31

ABC Transporters: Exporter

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ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
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Carrier-Mediated Transport01:06

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Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
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ABC Transporters: Importer01:27

ABC Transporters: Importer

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ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
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Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

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In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
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Membrane Transporters01:31

Membrane Transporters

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Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
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The Significance of Membrane Transport01:44

The Significance of Membrane Transport

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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
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Related Experiment Video

Updated: Oct 18, 2025

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
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Multidrug efflux transporter ABCG2: expression and regulation.

Samiksha Kukal1,2, Debleena Guin1,3, Chitra Rawat1,2

  • 1Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110007, India.

Cellular and Molecular Life Sciences : CMLS
|September 29, 2021
PubMed
Summary

Adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) regulates cellular homeostasis and drug resistance. Understanding ABCG2 regulation is key to overcoming multidrug resistance and managing related diseases.

Keywords:
ABCG2ATP-binding cassette transporterDrug resistanceEfflux transporterRegulationSignaling pathways

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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) is crucial for cellular homeostasis and drug resistance.
  • ABCG2 effluxes diverse molecules, but its expression is altered in various pathophysiological conditions.
  • Altered ABCG2 levels can impact drug bioavailability and disease severity.

Purpose of the Study:

  • To review the physiological role of ABCG2.
  • To explore factors modulating ABCG2 expression and activity.
  • To highlight signaling pathways and genetic factors in ABCG2 regulation.

Main Methods:

  • Literature review of ABCG2 function, regulation, and related signaling pathways.
  • Analysis of factors influencing ABCG2 expression and activity.
  • Examination of genetic polymorphisms affecting ABCG2.

Main Results:

  • ABCG2 plays a vital role in transporting endogenous and exogenous molecules.
  • Pathophysiological conditions significantly alter ABCG2 expression.
  • Complex signaling pathways (Kinases, Wnt/β-catenin, Sonic hedgehog) and genetic variations regulate ABCG2.

Conclusions:

  • Targeting ABCG2 regulation, not just its function, is crucial for therapeutic interventions.
  • A comprehensive understanding of ABCG2 regulation can identify targets for overcoming multidrug resistance.
  • This knowledge aids in managing ABCG2-related pathophysiology and improving therapeutic outcomes.