Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aneurysm Wall Enhancement in Patients With Unruptured Intracranial Aneurysm Using Aspirin or Statins: A Cross-Sectional Analysis of Three Prospective Cohorts.

AJNR. American journal of neuroradiology·2026
Same author

Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.

Human brain mapping·2026
Same author

TopCas: Topology-Gated Cas12a via DNA-RNA Chimeric Circular crRNA for Amplification-Free Nucleic Acid Detection and Conditional Gene Editing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Outcome Assessment in Stroke Using Multiparametric MRI: Integrating Infarct Location, Radiomics, and Global Brain Frailty.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Choroid plexus enlargement correlates with cognitive dysfunction and disease progression in Moyamoya disease.

Neurosurgical review·2025
Same author

Dynamic biosensing enables amplifier-collateral-cleavage enhancement for pathogen diagnostic.

Biosensors & bioelectronics·2025

Related Experiment Video

Updated: Oct 18, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.0K

Reduced functional network connectivity is associated with upper limb dysfunction in acute ischemic brainstem stroke.

Wen Geng1, Juan Zhang2, Song'an Shang1

  • 1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing, 210006, China.

Brain Imaging and Behavior
|September 29, 2021
PubMed
Summary

Brainstem stroke disrupts functional connectivity (FC) within and between brain networks. This disruption correlates with upper extremity motor impairment, suggesting FC analysis aids early diagnosis and predicts motor deficits.

Keywords:
Acute brainstem ischemic strokeFunctional network connectivityResting-state fMRIUpper limb dysfunction

More Related Videos

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System
07:35

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System

Published on: December 29, 2023

1.5K
Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
09:42

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

1.6K

Related Experiment Videos

Last Updated: Oct 18, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.0K
Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System
07:35

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System

Published on: December 29, 2023

1.5K
Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
09:42

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

1.6K

Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Acute brainstem ischemic stroke impacts neural networks.
  • Understanding functional connectivity (FC) changes is crucial for predicting motor deficits.

Purpose of the Study:

  • To detect alterations in intra- and inter-network FC in acute brainstem ischemic stroke.
  • To assess the relationship between FC and motor assessment scores for predicting upper extremity impairment.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) data from 50 acute brainstem ischemic stroke patients and 45 healthy controls (HCs).
  • Independent component analysis (ICA) for resting-state networks (RSNs) and functional network connectivity (FNC) analysis.
  • Correlation analysis to link FNC abnormalities with upper extremity motor impairment.

Main Results:

  • Altered FC observed within the default mode network (DMN), executive control network (ECN), salience network (SN), auditory network (AN), and cerebellum network (CN) in stroke patients compared to HCs.
  • Significant alterations in inter-network connectivity, including SN-CN, SN-AN, and ECN-DMN connections.
  • Correlations found between FNC disruptions and upper limb dysfunction measurements.

Conclusions:

  • Widespread FNC impairment and altered network integration occur in the acute stage of brainstem ischemic stroke.
  • FNC disruption is a potential biomarker for early diagnosis and prediction of upper limb dysfunction in these patients.