A multipoint linkage analysis program for X-linked disorders, with the example of Duchenne muscular dystrophy and...

The analysis of linkage data with multiple markers is a complex problem, only soluble with the help of computer programs. A package of programs is presented which allows the analysis of X-linked data with reasonable speed. Published data relating Duchenne muscular dystrophy and seven X-specific DNA probes are analysed. The results presented are the maximum likelihoods of the eight possible orders and the interlocus distances of the most likely order. Also calculated are the mean and standard deviation of risk for selected cases with information derived from both single probes and pair of probes bridging the disease locus.