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Prospects for the Global Elimination of Hepatitis B

Timothy M Block1, Kyong-Mi Chang2, Ju-Tao Guo1

  • 1Baruch S. Blumberg Institute, Doylestown, Pennsylvania 18902, USA;

Annual Review of Virology
|September 29, 2021
PubMed

Insights

Chronic hepatitis B (CHB) remains a major global health issue. New research focuses on understanding HBV pathobiology and developing curative therapies to eliminate hepatitis B by 2030.

Area of Science:

  • Hepatology and Virology
  • Infectious Diseases
  • Public Health

Background:

  • Chronic hepatitis B virus (HBV) infection causes significant mortality from liver cirrhosis and hepatocellular carcinoma.
  • Current treatments suppress HBV replication but do not offer a cure, hindering global elimination efforts.
  • The World Health Organization aims to eliminate viral hepatitis by 2030, necessitating advancements in CHB treatment.

Purpose of the Study:

  • To review recent research on HBV pathobiology.
  • To discuss the development of novel therapeutics for CHB cure.
  • To highlight strategies for achieving hepatitis B elimination.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of research progress in HBV pathobiology.
  • Evaluation of emerging therapeutic strategies for CHB.

Main Results:

  • Significant progress in understanding HBV's complex life cycle and disease mechanisms.
  • Development of novel therapeutic approaches targeting viral cure beyond suppression.
  • Identification of key areas for future research and clinical development.

Conclusions:

  • A cure for chronic hepatitis B is essential for meeting the 2030 elimination goal.
  • Continued research into HBV pathobiology and novel therapeutics is critical.
  • Integrated strategies for prevention and cure are needed to combat the global burden of hepatitis B.

Keywords:
chronic hepatitis Bdirect-acting antiviralsfunctional curehepatitis B virusimmunotherapy

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