High Levels of LINC01140 Expression Predict a Good Prognosis and Improve Radiotherapy in Sarcoma Patients

Long intergenic non-protein coding RNA has an important biological role in tumors. But, LINC01140 in sarcoma has not been studied yet. This study investigates the expression and prognosis role of LINC01140 in sarcoma. LINC01140 was lower in metastatic sarcoma, and low LINC01140 expression predicted poor overall survival, disease-free survival, and disease-specific survival in sarcoma. High LINC01140 expression and radiotherapy could promote survival of sarcoma. Gene set enrichment analysis showed LINC01140 was involved in interferon-gamma response, epithelial-mesenchymal transition, the interaction between cytokine receptors, and cholesterol homeostasis. Gene ontology enrichment analysis showed LINC01140 was involved in immunity, fatty acid metabolism, amino acid metabolism, cell division, serine/threonine-protein kinase. LINC01140 expression was negatively correlated with various epithelial-mesenchymal transition factors and positively correlated with the expression of anti-cancer factor hypermethylated-in-cancer 1. These results confirmed that LINC01140 may be a potential novel prognostic molecule in sarcoma.