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Updated: Oct 18, 2025
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Depression in Older Adults 12 Months After Traumatic Brain Injury: A TRACK-TBI Study
Jesse S Passler1, Angelle M Sander2, Nancy R Temkin3
1H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX; Brain Injury Research Center, TIRR Memorial Hermann, Houston, TX.
Objective:
To investigate depression at 12 months after traumatic brain injury (TBI) in older adults compared with younger adults.
Design:
Prospective longitudinal cohort study of persons with medically documented mild, moderate, and severe TBI at 12 months postinjury.
Setting:
Eighteen participating Level 1 trauma centers in the United States.
Participants:
Participants with TBI (N=1505) and primary outcome data at 12-month follow-up.
Interventions:
Not applicable.
Main Outcome Measures:
Patient Health Questionnaire-9 (PHQ-9).
Results:
PHQ-9 total scores were significantly lower for older adults (age≥65y; M=3.2) compared with younger adults (age<65y; M=5.0; B=-1.63, P<.001), indicating fewer depressive symptoms in older adults. Age did not interact with education, sex, race/ethnicity, psychiatric history, substance use, or Glasgow Coma Scale severity to affect PHQ-9 scores. Of the 29% of older adults who endorsed symptoms consistent with depression, 14% were classified as minor depression and 15% as major depression. The odds of older adults falling in the major depression vs no depression group were significantly lower (decreased by 56%) compared with younger adults (odds ratio=0.44, P=.001).
Conclusions:
At 12 months post-TBI, older adults endorse lower depressive symptoms than their younger counterparts and are less likely to experience major depression; however, over one-fourth of older adults endorsed symptoms consistent with depression, warranting evaluation and treatment.
