Modulation of NFκB signalling pathway by tocotrienol: A systematic review

Area of Science:

• Nutritional Biochemistry
• Molecular Biology
• Cell Signaling

Background:

• Tocotrienols possess diverse biological activities, including anticancer, anti-inflammatory, antioxidant, cardioprotective, and bone-protective effects.
• These effects are often linked to the modulation of the nuclear factor kappa B (NFκB) signaling pathway.
• Understanding the precise mechanisms is crucial for therapeutic applications.

Purpose of the Study:

• To systematically review and evaluate existing literature on the effects of tocotrienols on the NFκB signaling pathway.
• To identify and elucidate the potential molecular mechanisms involved in tocotrienol-mediated NFκB modulation.

Main Methods:

• A comprehensive literature search was performed using PubMed and SCOPUS databases.
• Keywords included "tocotrienol" and "NFκB" or "nuclear factor kappa b".
• Inclusion criteria focused on original English-language articles investigating tocotrienol's impact on NFκB signaling.

Main Results:

• Fifty-nine relevant articles were selected from an initial retrieval of 117.
• The review identified key mechanisms underlying tocotrienol's effects.
• Inhibition of farnesyl prenyl transferase was highlighted as a significant mechanism.

Conclusions:

• Tocotrienols effectively modulate the NFκB signaling pathway.
• The suppression of NFκB activation by tocotrienols involves mechanisms such as the inhibition of farnesyl prenyl transferase.
• This modulation contributes to the reported beneficial health effects of tocotrienols.