Fast data-driven learning of parallel MRI sampling patterns for large scale problems

In this study, a fast data-driven optimization approach, named bias-accelerated subset selection (BASS), is proposed for learning efficacious sampling patterns (SPs) with the purpose of reducing scan time in large-dimensional parallel MRI. BASS is applicable when Cartesian fully-sampled k-space measurements of specific anatomy are available for training and the reconstruction method for undersampled measurements is specified; such information is used to define the efficacy of any SP for recovering the values at the non-sampled k-space points. BASS produces a sequence of SPs with the aim of finding one of a specified size with (near) optimal efficacy. BASS was tested with five reconstruction methods for parallel MRI based on low-rankness and sparsity that allow a free choice of the SP. Three datasets were used for testing, two of high-resolution brain images ([Formula: see text]-weighted images and, respectively, [Formula: see text]-weighted images) and another of knee images for quantitative mapping of the cartilage. The proposed approach has low computational cost and fast convergence; in the tested cases it obtained SPs up to 50 times faster than the currently best greedy approach. Reconstruction quality increased by up to 45% over that provided by variable density and Poisson disk SPs, for the same scan time. Optionally, the scan time can be nearly halved without loss of reconstruction quality. Quantitative MRI and prospective accelerated MRI results show improvements. Compared with greedy approaches, BASS rapidly learns effective SPs for various reconstruction methods, using larger SPs and larger datasets; enabling better selection of sampling-reconstruction pairs for specific MRI problems.